{"product_id":"liposomal-vitamin-c-supplement","title":"Liposomal Vitamin C Supplement 500mg","description":"\u003cp\u003e\u003cb\u003eLIPOSOMAL VITAMIN C 500MG\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eThe Dose Makes the Difference. Liposomal Breaks the Absorption Ceiling.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWHAT IS VITAMIN C?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAscorbic acid (Vitamin C) is the most widely consumed supplement on the planet. It is also the most systematically under-dosed. The Recommended Daily Intake of 65–90mg was established to prevent scurvy — a threshold so low it is clinically meaningless for any application beyond preventing deficiency. The dose required for meaningful antioxidant, immune, collagen synthesis, and adrenal support effects is 500mg–2000mg daily. The problem is not the dose. The problem is the absorption ceiling.\u003c\/p\u003e\n\u003cp\u003eHumans lack the gene encoding L-gulonolactone oxidase (GULO) — the enzyme that synthesises Vitamin C endogenously. Every other mammal can synthesise Vitamin C on demand, dramatically upregulating production under stress. A goat under physiological stress produces approximately 13,000mg of Vitamin C per day. A human produces zero. We are entirely dependent on dietary and supplemental intake for a nutrient that our physiology deploys in gram quantities under stress — while standard supplementation delivers milligrams.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTHE MOLECULAR MECHANISMS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCollagen Synthesis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is an obligate cofactor for prolyl hydroxylase and lysyl hydroxylase — the enzymes that hydroxylate proline and lysine residues in collagen precursors (pro-alpha chains). Without hydroxylation, collagen triple helix formation fails. The resulting unstable proto-collagen cannot form the cross-links required for structural integrity in skin, tendon, cartilage, bone, and vascular walls. This is why Vitamin C depletion presents as scurvy — tissue disintegration at every structural level simultaneously. For athletes, this mechanism makes Vitamin C directly relevant to tendon and ligament health, joint cartilage maintenance, and scar tissue quality.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCatecholamine and Hormone Synthesis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe adrenal cortex contains the highest concentration of Vitamin C of any tissue in the body — because Vitamin C is required at two critical steps in catecholamine biosynthesis. Dopamine-beta-hydroxylase, which converts dopamine to noradrenaline, requires Vitamin C as an electron donor. Peptidylglycine alpha-amidating monooxygenase (PAM), required for the maturation of numerous neuropeptides and peptide hormones, also requires Vitamin C. Under acute physiological stress, the adrenal glands rapidly release their Vitamin C stores into circulation — explaining the stress-responsive upregulation of Vitamin C synthesis observed in other mammals.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAntioxidant Network — Primary Aqueous Phase Antioxidant\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAscorbate is the primary water-soluble antioxidant in both intracellular and extracellular aqueous environments. It directly scavenges superoxide, hydroxyl radicals, and singlet oxygen. After oxidation to dehydroascorbate (DHA), it is regenerated to ascorbate by glutathione (consuming GSH) or by NADPH-dependent dehydroascorbate reductase. Vitamin C thus acts as the primary electron source for regenerating the glutathione antioxidant network — feeding GSH and allowing it to regenerate Vitamin E in turn. Adequate Vitamin C is foundational to the entire cellular antioxidant hierarchy.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eImmune Function\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eNeutrophils and lymphocytes accumulate Vitamin C to concentrations 100× higher than plasma — using it to support oxidative burst activity in neutrophils (Vitamin C regenerates the oxidised proteins damaged by the burst), and to support lymphocyte proliferation and cytokine production. Intravenous Vitamin C at gram doses has demonstrated reduction in duration of critical illness in multiple RCTs. The mechanism is not placebo — it is restoration of immune cell Vitamin C pools that are rapidly depleted during infection.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTHE ABSORPTION CEILING PROBLEM\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is absorbed in the small intestine via SVCT1 (sodium-dependent Vitamin C transporter 1) — a saturable, active transport system. At doses of 30–180mg, absorption is approximately 80–90%. As dose increases, the transporter becomes saturated and absorption efficiency drops sharply: at 500mg, approximately 63% is absorbed; at 1000mg, approximately 47%; at 2000mg, approximately 33%. Unabsorbed Vitamin C passes to the colon where it draws osmotic water, causing loose stools — the well-known 'bowel tolerance' effect that limits oral Vitamin C dosing. This is not a problem with the molecule. It is a problem with passive delivery relying on a saturable transporter.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTHE LIPOSOMAL ADVANTAGE\u003c\/b\u003e\u003c\/p\u003e\n\u003ctable cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003eStandard Oral Vitamin C at 500mg\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003e~63% — transporter beginning to saturate.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003eStandard Oral Vitamin C at 1000mg\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003e~47% — significant saturation, increasing GI side effects.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003eStandard Oral Vitamin C at 2000mg\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003e~33% — majority wasted, significant osmotic laxative effect.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003eSpawn Nutra Liposomal Vitamin C 500mg\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"middle\"\u003e\n\u003cp\u003e\u003cb\u003e~70–90% effective bioavailability — independent of SVCT1 saturation. Liposomal delivery bypasses the transporter-dependent pathway entirely. Nanovesicles are absorbed via endocytosis, releasing ascorbate intracellularly. No GI side effects. No bowel tolerance ceiling. Consistent absorption regardless of dose or prior intake.\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eLiposomal Vitamin C produces plasma Vitamin C levels that are significantly higher and more sustained than equivalent oral doses. Published studies (Hickey et al., 2008; Davis et al., 2016) demonstrate plasma concentrations with liposomal Vitamin C that approach those of IV administration at oral doses — the closest commercially available alternative to intravenous supplementation.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMAD SCIENTIST 5150 — FORMULATE TO DESTROY\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEvery other Vitamin C product is limited by a transporter that saturates at 180mg. Above that, you are mostly supplementing the toilet. Spawn Nutra Liposomal Vitamin C bypasses the transporter entirely. 70–90% bioavailability. No ceiling. No GI side effects. Actual Vitamin C supplementation, not theatre.\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":52376017469752,"sku":"VITC500","price":29.25,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0998\/3970\/5400\/files\/SN_LIPO-VITAMIN-C_500.jpg?v=1778841768","url":"https:\/\/www.spawn-nutra.com.au\/products\/liposomal-vitamin-c-supplement","provider":"SpawqnStoreLatest","version":"1.0","type":"link"}